壳聚糖基水凝胶伤口敷料的研究进展

Advances in Research of Chitosan-based Hydrogel Wound Dressings

关键词:  壳聚糖  水凝胶  伤口敷料

Key Words:chitosan  hydrogel  wound dressing

摘要:壳聚糖是一种天然的阳离子型多糖，由于其分子链上含有丰富的氨基和羟基基团，可以通过分子间的相互作用来构筑多功能水凝胶。壳聚糖基伤口敷料因其具有对创伤较好的保护和促进创伤愈合等特性而被广泛用于临床。本文从抗菌性、生物相容性、伤口贴合性、抗氧化性等方面，对壳聚糖及其衍生物的性能特征进行了综述，分析了壳聚糖基水凝胶伤口敷料的发展趋势，并对其发展前景进行了展望。

Abstract:Chitosan， as a natural cationic polysaccharide， can be able to build multifunctional hydrogels by intermolecular interactions due to the large number of amino and hydroxyl groups on its chains. Chitosan-based wound dressings are widely used in clinical practice because of their ability to protect wounds and promote their healing. The properties of chitosan and its derivatives were reviewed in this paper， including antibacterial， biocompatibility， wound adhesion， and antioxidant properties. The development trend of chitosan hydrogel wound dressing was analyzed， and its potential for future development was prospected.